Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation
نویسندگان
چکیده
منابع مشابه
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation
Bone undergoes continuous remodelling throughout adult life, and the equilibrium between bone formation by osteoblasts and bone resorption by osteoclasts defines the final bone mass. Here we show that Snail1 regulates this balance by controlling osteoblast differentiation. Snail1 is necessary for the early steps of osteoblast development, and it must be downregulated for their final differentia...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2009
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2009.23